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miR-21 expression predicts prognosis in diffuse large B-cell lymphoma.

Jing Li¹, Rong Fu², Liping Yang³

¹Department of Hematology, Tianjin Medical University General HospitalTianjin 300052, China; Department of Hematology, Shangyu People's HospitalShangyu 312300, Shaoxing, Zhejiang, China.

International Journal of Clinical and Experimental Pathology

|January 30, 2016

Summary

Serum miR-21 is elevated in diffuse large B cell lymphoma (DLBCL) and indicates a poorer prognosis. This microRNA shows potential as a novel biomarker for predicting DLBCL patient survival outcomes.

Keywords:

MicroRNA-21 diffuse large B-cell lymphoma prognosis

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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

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Area of Science:

Oncology
Molecular Biology
Biomarker Discovery

Background:

MicroRNAs (miRNAs) in serum are recognized as potential biomarkers for diverse diseases.
Investigating serum miR-21 expression in diffuse large B cell lymphoma (DLBCL) is crucial for understanding its role.

Purpose of the Study:

To determine the expression level of miR-21 in DLBCL patients.
To evaluate the prognostic value of serum miR-21 in DLBCL.

Main Methods:

Serum samples from 112 DLBCL patients and 45 healthy controls were analyzed using quantitative real-time polymerase chain reaction (qRT-PCR).
Statistical analyses included chi-square, Kaplan-Meier, and Cox regression to assess associations with clinicopathologic parameters and survival.

Main Results:

Serum miR-21 was significantly upregulated in DLBCL patients compared to controls.
Higher miR-21 expression correlated with B symptoms, IPI score, and specific treatments (P<0.05).
Elevated miR-21 was linked to worse overall survival and identified as an independent prognostic marker (P=0.001, HR: 4.404).

Conclusions:

Serum miR-21 expression is a potential novel biomarker for predicting DLBCL prognosis.
miR-21 warrants further investigation as a diagnostic and prognostic tool in DLBCL.