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Homocysteine, endothelin-1 and nitric oxide in patients with hypertensive disorders complicating pregnancy

Yachang Zeng1, Mujun Li1, Yue Chen1

  • 1Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangxi Medical University Nanning 530021, Guangxi, PR China.

International Journal of Clinical and Experimental Pathology
|January 30, 2016
PubMed

Insights

This study found that higher levels of serum homocysteine (Hcy) and endothelin-1 (ET-1), and lower levels of nitric oxide (NO), are associated with hypertensive disorders of pregnancy (HDCP). Measuring these markers can help assess disease incidence and progression.

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Research
  • Biochemistry

Background:

  • Hypertensive disorders of pregnancy (HDCP) represent a significant complication in gestation.
  • Understanding the biochemical markers associated with HDCP is crucial for effective management.

Purpose of the Study:

  • To investigate the alterations in serum homocysteine (Hcy), endothelin-1 (ET-1), and nitric oxide (NO) levels in patients with HDCP.
  • To determine the clinical significance of these markers in relation to disease severity.

Main Methods:

  • Serum concentrations of Hcy, ET-1, and NO were measured in 239 patients with HDCP (mild and severe preeclampsia) and 200 healthy pregnant women.
  • Assays used included enzymatic cycling for Hcy, ELISA for ET-1, and nitrate reductase for NO.

Main Results:

  • Patients with HDCP exhibited significantly higher serum Hcy and ET-1 levels and lower NO levels compared to controls (P<0.05).
  • Both mild and severe preeclampsia groups showed these significant differences compared to controls.
  • Higher Hcy and ET-1 levels and lower NO levels were observed in severe preeclampsia compared to mild preeclampsia (P<0.05).
  • Serum Hcy and ET-1 positively correlated with disease severity, while NO negatively correlated (P<0.05).

Conclusions:

  • Serum Hcy, ET-1, and NO are significantly associated with the pathogenesis of HDCP.
  • Comprehensive measurement of these biomarkers can effectively evaluate the incidence and progression of HDCP.
Abstract

Keywords:
Gestational hypertensionendothelin-1homocysteinenitric oxide

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