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Related Experiment Videos

Limbic-striatal interactions in reward-related processes.

T W Robbins1, M Cador, J R Taylor

  • 1Department of Experimental Psychology, University of Cambridge, U.K.

Neuroscience and Biobehavioral Reviews
|January 1, 1989
PubMed
Summary
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Dopamine (DA) in the ventral striatum enhances responses to conditioned reinforcers. The amygdala, not DA depletion, is crucial for choosing conditioned reinforcers, suggesting distinct roles in reward learning.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Neuropharmacology

Background:

  • Conditioned reinforcers acquire motivational properties through association with primary rewards.
  • Dopamine (DA) plays a critical role in reward processing and motivation.
  • The ventral striatum and amygdala are key brain regions implicated in reward learning and motivated behavior.

Purpose of the Study:

  • To investigate the role of dopamine in the ventral striatum in mediating the incentive properties of conditioned reinforcers.
  • To examine the involvement of the basolateral amygdala in the choice behavior related to conditioned reinforcers.
  • To explore the dissociation between stimulus-response and stimulus-reward associative mechanisms.

Main Methods:

  • Infusions of d-amphetamine and dopamine into the ventral striatum.

Related Experiment Videos

  • 6-hydroxydopamine (6-OHDA) lesions of the ventral and dorsal striatum.
  • Excitotoxic lesions of the basolateral nucleus of the amygdala.
  • Second-order schedules of reinforcement and conditional visuo-spatial discrimination tasks.

    • Main Results:

    • Ventral striatal DA enhanced responding for a conditioned reinforcer (light predicting water).
    • These effects were blocked by ventral striatal 6-OHDA lesions, mimicking DA infusion effects.
    • Amygdala lesions, but not ventral striatal DA depletion, attenuated the choice of the conditioned reinforcer.
    • Discriminative properties of reward-related stimuli and primary motivation were preserved after amygdala lesions.

    Conclusions:

    • Ventral striatal dopamine modulates the incentive salience of conditioned reinforcers.
    • The basolateral amygdala interacts with ventral striatal DA systems to guide choice behavior towards conditioned reinforcers.
    • A dissociation exists between dorsal striatum-mediated stimulus-response (habit) learning and ventral striatum/amygdala-mediated stimulus-reward learning.