Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atomic Force Microscopy01:08

Atomic Force Microscopy

4.7K
Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
4.7K
Overview of Microscopy Techniques01:22

Overview of Microscopy Techniques

17.7K
The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...
17.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Customizing Ionic Micelles by Dynamic Coassembly of Sequence-Defined Peptoid Block Copolymers.

Macromolecules·2026
Same author

Spatio-temporal evolution analysis of land-use carbon effects driven by new quality productive forces: a case study of Hubei province.

Scientific reports·2026
Same author

Programmable Electrostatics in Charge-Patterned Polypeptoid Micelles Probed by Small-Angle Neutron Scattering.

Macromolecules·2026
Same author

CCDC120 phase separation contributes to desmosomal integrity and cardiac function.

Nature communications·2026
Same author

Corona Chain-Controlled Transition from Ostwald Ripening-Grown Hexagonal Platelets to Screw-Dislocation Spirals in Liquid-Crystalline Polypeptoids.

Nano letters·2026
Same author

Ferroptosis-STING co-activation drives GzmB<sup>+</sup>CD38<sup>+</sup>CD8<sup>+</sup> T-cell expansion to overcome lymphoma immunosuppression.

Biomaterials·2026
Same journal

Advances in application of microplasmas for non-metallic species analysis by optical spectrometry.

The Analyst·2026
Same journal

Sulfur vacancy-mediated self-photocatalysis-boosted electrochemiluminescence sensing <i>via</i> molecular oxygen activation for sensitive detection of isocarbophos.

The Analyst·2026
Same journal

Analytical challenges in mapping the subcellular metabolome and lipidome.

The Analyst·2026
Same journal

Threshold-guided multiplex PCR-LFA: a step toward UTI pathogen detection.

The Analyst·2026
Same journal

Aptamer-based CRISPR-Cas12a fluorescent biosensors for serum biomarker detection.

The Analyst·2026
Same journal

A two-step centrifugal microfluidic platform for semi-automated IGRA detection of tuberculosis based on chemiluminescence.

The Analyst·2026
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

High-Speed Atomic Force Microscopy Imaging of DNA Three-Point-Star Motif Self Assembly Using Photothermal Off-Resonance Tapping
08:59

High-Speed Atomic Force Microscopy Imaging of DNA Three-Point-Star Motif Self Assembly Using Photothermal Off-Resonance Tapping

Published on: March 22, 2024

1.2K

Sample stage designed for force modulation microscopy using a tip-mounted AFM scanner.

Lu Lu1, Song Xu2, Donghui Zhang1

  • 1Department of Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA 70803, USA. jgarno@lsu.edu.

The Analyst
|January 30, 2016
PubMed
Summary
This summary is machine-generated.

A novel sample stage for force modulation microscopy (FMM) enables high-resolution mechanical property mapping of complex nanostructures. This accessory, designed for tip-mounted scanning probe microscopy (SPM) scanners, provides excellent resolution in ambient conditions.

More Related Videos

Atomic Force Microscopy of Red-Light Photoreceptors Using PeakForce Quantitative Nanomechanical Property Mapping
14:13

Atomic Force Microscopy of Red-Light Photoreceptors Using PeakForce Quantitative Nanomechanical Property Mapping

Published on: October 24, 2014

12.2K
Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid
10:25

Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid

Published on: December 20, 2016

17.6K

Related Experiment Videos

Last Updated: Mar 26, 2026

High-Speed Atomic Force Microscopy Imaging of DNA Three-Point-Star Motif Self Assembly Using Photothermal Off-Resonance Tapping
08:59

High-Speed Atomic Force Microscopy Imaging of DNA Three-Point-Star Motif Self Assembly Using Photothermal Off-Resonance Tapping

Published on: March 22, 2024

1.2K
Atomic Force Microscopy of Red-Light Photoreceptors Using PeakForce Quantitative Nanomechanical Property Mapping
14:13

Atomic Force Microscopy of Red-Light Photoreceptors Using PeakForce Quantitative Nanomechanical Property Mapping

Published on: October 24, 2014

12.2K
Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid
10:25

Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid

Published on: December 20, 2016

17.6K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Surface Science

Background:

  • Force Modulation Microscopy (FMM) is a Scanning Probe Microscopy (SPM) technique used for acquiring mechanical properties alongside topographic data.
  • FMM is particularly valuable for analyzing polymer and organic thin film samples, enabling high-resolution qualitative evaluation of mixed domains in copolymers or composite films.

Purpose of the Study:

  • To design and test a novel, generic sample stage accessory for FMM experiments.
  • To enable FMM measurements for SPM configurations utilizing a tip-mounted scanner.
  • To facilitate z-sample modulation for enhanced mechanical property analysis.

Main Methods:

  • A custom sample stage was constructed from machined polycarbonate, incorporating a piezoactuator for z-direction sample vibration.
  • The FMM sample stage was evaluated using test samples with nanoscale dimensions and increasingly complex surface morphologies, including nanoholes in organosilanes, mixed organosilanes on Si(111), and a cyclic gel polymer with nanostructures.
  • Frequency spectra were acquired for different sample domains to analyze local mechanical responses.

Main Results:

  • The home-constructed sample stage achieved excellent resolution in ambient conditions for complex and multi-component samples.
  • Distinct differences in local mechanical responses were revealed through frequency spectra analysis of various sample domains.
  • The stage proved effective for evaluating simple (two-domain) and complex (three-region) nanostructured surfaces.

Conclusions:

  • A practical and effective approach for constructing a sample stage accessory for z-sample modulation in FMM experiments with tip-mounted SPM scanners was demonstrated.
  • The developed stage facilitates high-resolution mechanical characterization of diverse nanostructured materials.
  • This accessory broadens the applicability of FMM for detailed analysis of material properties at the nanoscale.