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Related Concept Videos

Upstream Processing01:27

Upstream Processing

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Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
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Freshwater Microbial Ecology01:24

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Freshwater systems such as streams, rivers, and lakes exhibit distinct physical and biological characteristics that influence their microbial communities. These environments are broadly categorized into lotic systems—those with flowing waters like streams and most rivers—and lentic systems, which include still or slow-moving waters such as lakes, ponds, and marshes.In lentic systems, phytoplankton drive primary production, generating autochthonous organic carbon. In contrast, lotic...
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Rapidly varying flow (RVF) in open channels is characterized by abrupt changes in flow depth over a short distance, with the rate of depth change relative to distance often approaching unity. These flows are inherently complex due to their transient and multi-dimensional nature, making exact analysis difficult. However, approximate solutions using simplified models provide valuable insights into their behavior.Key Features of Rapidly Varying FlowRVF is commonly observed in scenarios involving...
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Updated: Mar 26, 2026

Window on a Microworld: Simple Microfluidic Systems for Studying Microbial Transport in Porous Media
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Upstream Swimming in Microbiological Flows.

Arnold J T M Mathijssen1, Tyler N Shendruk1, Julia M Yeomans1

  • 1The Rudolf Peierls Centre for Theoretical Physics, 1 Keble Road, Oxford OX1 3NP, United Kingdom.

Physical Review Letters
|January 30, 2016
PubMed
Summary
This summary is machine-generated.

Microswimmers in non-Newtonian fluids exhibit unique upstream migration patterns. Viscoelastic normal stresses reorient swimmers, enabling centerline migration and offering a novel microbe sorting mechanism based on swimming speed.

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Area of Science:

  • Fluid dynamics
  • Microbiology
  • Biophysics

Background:

  • Microorganism interactions with fluid environments are crucial.
  • Understanding microswimmer behavior in complex flows is essential for biological systems.

Purpose of the Study:

  • To model microswimmer dynamics in non-Newtonian Poiseuille flows.
  • To investigate the effects of fluid rheology on microswimmer migration and orientation.

Main Methods:

  • Development of a theoretical model for microswimmer dynamics.
  • Simulation of microswimmer behavior in shear-thickening and shear-thinning fluids.
  • Analysis of viscoelastic normal stress effects on swimmer orientation and migration.

Main Results:

  • Microswimmers migrate upstream faster in shear-thickening fluids and slower in shear-thinning fluids compared to Newtonian fluids.
  • Viscoelastic normal stresses reorient swimmers towards the centerline.
  • Centerline migration is observed, contrasting with boundary accumulation in quiescent Newtonian fluids.

Conclusions:

  • Non-Newtonian fluid properties significantly alter microswimmer migration dynamics.
  • Viscoelastic normal stresses provide a mechanism for centerline accumulation.
  • A potential sorting mechanism for microbes based on swimming speed is proposed.