Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

2.8K
Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various...
2.8K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

4.8K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.8K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

1.4K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.4K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

711
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
711
Hypertension I: Introduction01:28

Hypertension I: Introduction

1.2K
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
1.2K
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

2.4K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors Associated with Aortic Valve Calcification in Type 2 Diabetes - A Steno INTEN-CT substudy.

European heart journal. Cardiovascular Imaging·2026
Same author

Obstructive sleep apnoea is associated with accelerated progression of diabetic kidney disease.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same author

Thoracoscopic Sympathectomy in Treatment-Resistant Essential Hypertension: A Novel Approach to Reduce Sympathetic Activity and Blood Pressure.

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension·2026
Same author

Progression to type 2 diabetes among post-myocardial infarction patients with overweight or obesity: a real-world cohort study.

Cardiovascular diabetology·2026
Same author

Study protocol for the investigator-initiated Danish pragmatic randomised STENO INTEN-CT trial: does screening and intervention for subclinical coronary artery disease in type 2 diabetes reduce cardiovascular events?

BMJ open·2025
Same author

Obstructive sleep apnea is associated with cardiac structural and functional alterations in patients with advanced diabetic kidney disease.

Diabetes research and clinical practice·2025

Related Experiment Video

Updated: Mar 26, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

815

Hypertension and Diabetic Nephropathy.

Jeppe Skov, Jens Sandahl Christiansen, Per Løgstrup Poulsen

    Endocrine Development
    |January 30, 2016
    PubMed
    Summary

    Diabetic nephropathy (DN) is a leading cause of kidney failure and cardiovascular events in diabetes patients. Effective management involves blood pressure control and glucose monitoring, with ongoing research for new treatments.

    Area of Science:

    • Nephrology
    • Endocrinology
    • Cardiology

    Background:

    • Diabetic nephropathy (DN) is a significant complication of type 1 and type 2 diabetes.
    • DN is a primary cause of end-stage renal disease and increases cardiovascular event risk.
    • Key characteristics include elevated urinary albumin, high blood pressure (BP), and declining renal function.

    Purpose of the Study:

    • To review the role of blood pressure control in managing diabetic nephropathy.
    • To highlight the importance of glucose level management alongside BP control.
    • To identify unmet needs and emerging treatments for DN.

    Main Methods:

    • Review of current literature on diabetic nephropathy management.
    • Focus on antihypertensive agents, particularly ACE inhibitors and ARBs.

    More Related Videos

    Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
    08:35

    Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

    Published on: May 26, 2022

    4.4K
    Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
    08:15

    Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

    Published on: May 10, 2024

    1.0K

    Related Experiment Videos

    Last Updated: Mar 26, 2026

    Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
    10:31

    Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

    Published on: May 2, 2025

    815
    Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
    08:35

    Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

    Published on: May 26, 2022

    4.4K
    Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
    08:15

    Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

    Published on: May 10, 2024

    1.0K
  • Emphasis on BP and glucose control strategies.

    • Main Results:

    • Antihypertensive agents, especially ACE inhibitors and ARBs, are crucial for DN prevention and treatment.
    • BP control is a primary focus, with tight glucose control being equally vital.
    • Existing treatments address BP and glucose but new options are needed.

    Conclusions:

    • Blood pressure and glucose control are paramount in managing diabetic nephropathy.
    • ACE inhibitors and ARBs offer benefits beyond BP reduction.
    • Further research is necessary to identify and validate novel therapeutic strategies for DN.