Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Oral Microbiota01:28

Development of the Oral Microbiota

19
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
19
Teratogenicity01:07

Teratogenicity

4.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.5K
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

1.3K
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
1.3K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

4.3K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.3K
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

634
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
634
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

1.2K
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Impact of Social Deprivation on the Population Burden of Critical Illness-Related Mortality in the United States.

Critical care medicine·2025
Same author

Covert Encephalopathy Among Critically Ill Patients: Potential Implications for Daily Care.

Critical care medicine·2025
Same author

Comparative Evaluation of Risk of Death in Mechanically Ventilated Patients With COVID-19 and Influenza: A Population-Based Cohort Study.

Journal of clinical medicine research·2025
Same author

Trends in hospital mortality of patients with status epilepticus in the ICU before and during the COVID-19 pandemic.

Medicine·2025
Same author

Risk- and Probability-Based Timing of Antibiotics and Outcomes of Patients With Suspected Serious Infection: Did the COVID-19 Pandemic Affect Processes and Outcomes?

Critical care medicine·2024
Same author

Long-term outcomes of critically ill patients with hematological malignancies: what is the impact of the coronavirus disease 2019 pandemic?

Intensive care medicine·2024

Related Experiment Video

Updated: Mar 26, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K

Pregnancy-associated severe sepsis.

Lavi Oud1

  • 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas, USA.

Current Opinion in Obstetrics & Gynecology
|January 31, 2016
PubMed
Summary
This summary is machine-generated.

Pregnancy-associated severe sepsis (PASS) is a rare but increasing public health concern, particularly for vulnerable populations. Despite advances, timely diagnosis and care remain challenging, leading to rising mortality rates.

More Related Videos

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

7.1K
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.7K

Related Experiment Videos

Last Updated: Mar 26, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

7.1K
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.7K

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Pregnancy-associated severe sepsis (PASS) presents unique challenges due to limited contemporary data and inconsistent terminology.
  • While rare, the incidence of PASS is increasing in high-resource settings, disproportionately affecting underserved populations.

Purpose of the Study:

  • To review current knowledge on the burden, clinical features, management, and outcomes of PASS.
  • To identify gaps in understanding and highlight areas for improved clinical practice and research.

Main Methods:

  • Literature review of contemporary data on pregnancy-associated severe sepsis.
  • Analysis of reported incidence, risk factors, clinical manifestations, and treatment strategies.
  • Evaluation of outcomes, including mortality rates and long-term sequelae.

Main Results:

  • Data on PASS are sparse, with rising incidence in high-resource countries, affecting vulnerable groups.
  • Effective management hinges on clinician vigilance, rapid antimicrobial therapy, and organ support.
  • Timely diagnosis and care delivery are significant challenges, contributing to unchanged case fatality rates and rising mortality.

Conclusions:

  • PASS represents a growing public health threat in the obstetric population.
  • Consistent provision of time-sensitive care for PASS remains a critical challenge.
  • Further research is needed to understand long-term sequelae and improve patient outcomes.