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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Updated: Mar 26, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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Defining the threshold for too sick for transplant.

Jennifer C Lai1

  • 1University of California, San Francisco, California, USA.

Current Opinion in Organ Transplantation
|January 31, 2016
PubMed
Summary

Deciding when a liver transplant candidate is too sick requires evaluating physical frailty. Objective assessments help quantify risks from conditions like age, sarcopenia, and comorbidities.

Area of Science:

  • Hepatology
  • Transplant Surgery
  • Geriatrics

Background:

  • Determining transplant eligibility for patients on the liver transplant wait-list is complex.
  • Patients initially suitable may become too ill for surgery during the waiting period.

Purpose of the Study:

  • To review conditions that can make liver transplant candidates too sick for surgery.
  • To introduce a framework for assessing physical frailty in wait-listed patients.

Main Methods:

  • Review of common conditions arising on the wait-list: advancing age, sarcopenia, acute on chronic liver failure, and non-liver-related comorbidities.
  • Conceptualizing physical frailty as a measure of conditions unlikely to reverse post-transplant.
  • Emphasis on objective, repeatable pretransplant assessments.

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Main Results:

  • Conditions like age, sarcopenia, ACLF, and comorbidities can individually or in combination render a patient too sick for transplant.
  • Physical frailty quantifies the impact of these conditions on post-transplant outcomes.
  • Objective frailty assessments can predict reduced quality and quantity of life.

Conclusions:

  • A framework using objective pretransplant physical frailty assessments is proposed.
  • This framework aids clinicians in deciding when a patient is too sick for liver transplantation.
  • Facilitates informed decisions regarding transplant candidacy.