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Related Experiment Videos

Ion pair transport across membranes.

R Neubert1

  • 1Sektion Pharmazie, Martin-Luther-Universität, DDR, Halle/Saale.

Pharmaceutical Research
|September 1, 1989
PubMed
Summary

Ion pair transport (IPT) enhances drug lipophilicity and membrane permeation. This strategy is crucial for improving the bioavailability of hydrophilic drugs by modifying their properties.

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Area of Science:

  • Pharmacology
  • Drug Delivery
  • Physical Chemistry

Background:

  • Polar drugs often exhibit poor bioavailability due to limited lipophilicity and membrane transport.
  • Ion pair transport (IPT) is a strategy to overcome these limitations.

Purpose of the Study:

  • To review drugs and counter-ions suitable for ion pair transport.
  • To discuss the mechanisms underlying IPT and its impact on drug properties.

Main Methods:

  • Literature review of ion pairing agents and their application in drug transport.
  • Analysis of proposed mechanisms for ion pair formation and membrane permeation.

Main Results:

  • Ion pairing significantly increases the lipophilicity of polar drugs.
  • Enhanced lipophilicity leads to a higher transport rate across lipid membranes.

Conclusions:

  • Ion pair formation is an effective method to improve the bioavailability of hydrophilic, ionizable drugs.
  • A substantial alteration in drug properties is essential for successful IPT and enhanced absorption.

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