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Platelet reactivity in twin pregnancies
Takeshi Umazume1, Takahiro Yamada1, Mamoru Morikawa1
1Department of Obstetrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Thrombosis Research
|January 31, 2016
Summary
Platelets show increased reactivity in twin pregnancies during the second trimester, potentially explaining lower platelet counts later in gestation. This finding highlights differences in platelet behavior between singleton and twin pregnancies.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Perinatology
Background:
- Gestational thrombocytopenia is more common in twin pregnancies than singleton pregnancies.
- The reactivity of platelets in twin versus singleton pregnancies remains unclear.
Purpose of the Study:
- To investigate whether platelets exhibit increased reactivity in twin pregnancies compared to singleton pregnancies.
- To explore the relationship between platelet reactivity and platelet count changes during pregnancy.
Main Methods:
- Examined spontaneous platelet aggregation and platelet count changes in citrated whole blood (CWB) over 90 minutes post-sampling.
- Analyzed samples from 59 women with singleton and 17 women with twin pregnancies.
- Measured plasma soluble P-selectin (sP-selectin) levels.
Main Results:
- During the second trimester, twin pregnancies showed significantly higher platelet aggregation and a greater decrease in platelet count compared to singleton pregnancies.
- Third-trimester twin pregnancies had significantly lower platelet counts and increased mean platelet volume.
- Elevated third-trimester soluble P-selectin per platelet was observed in twin pregnancies.
Conclusions:
- Platelets are demonstrably more reactive in the second trimester of twin pregnancies compared to singleton pregnancies.
- Enhanced platelet reactivity in twin pregnancies may contribute to the observed decrease in platelet count during the third trimester.
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