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Updated: Mar 26, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
Published on: May 22, 2013
Nutrition and lifestyle in healthy aging: the telomerase challenge
Virginia Boccardi1, Giuseppe Paolisso2, Patrizia Mecocci1
1Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Abstract:
Nutrition and lifestyle, known to modulate aging process and age-related diseases, might also affect telomerase activity. Short and dysfunctional telomeres rather than average telomere length are associated with longevity in animal models, and their rescue by telomerase maybe sufficient to restore cell and organismal viability. Improving telomerase activation in stem cells and potentially in other cells by diet and lifestyle interventions may represent an intriguing way to promote health-span in humans.
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