Report: Sensitivity pattern of ceftriaxone against different clinical isolates
Rabia Bushra1, Ali Akbar Sial1, Mehwish Rizvi1
1Ziauddin College of Pharmacy, Ziauddin University, Karachi, Pakistan.
Pakistan Journal of Pharmaceutical Sciences
|February 1, 2016
Summary
Ceftriaxone antibiotic sensitivity is decreasing in Pakistan, with high resistance observed in Klebsiella pneumoniae. Continuous surveillance is crucial for effective antimicrobial therapy against emerging bacterial resistance.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Emerging antibiotic resistance to broad-spectrum antibiotics is a significant global health issue.
- Ceftriaxone, a third-generation cephalosporin, is vital for treating severe bacterial infections, especially those resistant to other drugs.
Purpose of the Study:
- To assess the current in-vitro sensitivity patterns of ceftriaxone (30μg/disk) against various clinical bacterial isolates.
- To identify specific pathogens exhibiting resistance to ceftriaxone in Karachi, Pakistan.
Main Methods:
- Disk-diffusion technique using 0.5 McFarland standard was employed.
- Three hundred clinical isolates, including Escherichia coli, Staphylococcus aureus, Salmonella typhi, and Klebsiella pneumoniae, were tested.
Main Results:
- Ceftriaxone demonstrated high sensitivity against Escherichia coli (90%) but lower sensitivity against Klebsiella pneumoniae (65%).
- Significant variations in sensitivity were noted among different bacterial species.
Conclusions:
- Ceftriaxone sensitivity is declining compared to previous studies, indicating a concerning trend in antimicrobial resistance.
- Ongoing monitoring of clinical pathogen resistance is essential for guiding effective antimicrobial strategies.
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