Sweet Syndrome: A Review and Update

Area of Science:

• Dermatology
• Immunology

Background:

• Sweet syndrome is a key example of febrile neutrophilic dermatoses.
• It characteristically presents with fever, neutrophilia, and tender, erythematous skin lesions.

Purpose of the Study:

• To provide a concise review of Sweet syndrome.
• To update information on its pathogenesis, classification, diagnosis, and treatment.

Main Methods:

• Literature review of Sweet syndrome.
• Synthesis of current understanding of pathogenesis, classification, diagnosis, and treatment.

Main Results:

• Sweet syndrome involves neutrophilic infiltration of the upper dermis.
• The etiology may involve a hypersensitivity reaction with cytokine involvement and neutrophil infiltration.
• Systemic corticosteroids are the standard first-line treatment.

Conclusions:

• Sweet syndrome requires understanding of its complex pathogenesis.
• Accurate diagnosis and appropriate treatment, primarily corticosteroids, are crucial.
• Further research into etiology may reveal novel therapeutic targets.