Monoterpenoid Bisindole Alkaloids

Area of Science:

• Natural Product Chemistry
• Organic Chemistry
• Phytochemistry

Background:

• Bisindole alkaloids represent a significant class of plant-derived secondary metabolites.
• These compounds are predominantly found in plant families such as Apocynaceae and Loganiaceae.
• Literature review focuses on compounds published up to June 2015.

Purpose of the Study:

• To comprehensively review the literature on bisindole alkaloids.
• To describe bisindole alkaloids isolated from Apocynaceae and Loganiaceae plant families.
• To outline recent synthetic approaches for monoterpenoid bisindole alkaloids.

Main Methods:

• Literature search and compilation of published data up to June 2015.
• Classification and description of isolated bisindole alkaloids based on structural types (e.g., Iboga-vobasine, Aspidosperma-Aspidosperma).
• Review of synthetic methodologies reported for monoterpenoid bisindole alkaloids.

Main Results:

• Detailed description of various bisindole alkaloid types, including Iboga-vobasine, Aspidosperma-Aspidosperma, eburnan-Aspidosperma, Strychnos-Strychnos, and macroline-macroline types.
• Inclusion of alkaloids isolated from Apocynaceae and Loganiaceae families.
• Summary of recent advancements in the synthesis of these complex natural products.

Conclusions:

• The chapter provides a valuable resource on bisindole alkaloids, consolidating knowledge up to mid-2015.
• It highlights the structural diversity and botanical origins of these compounds.
• Recent synthetic efforts demonstrate progress in accessing these complex molecular architectures.