Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pain01:20

Pain

1.8K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.8K
Analgesia and Pain Management01:25

Analgesia and Pain Management

2.9K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
2.9K
Nociception01:44

Nociception

34.6K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
34.6K
Empathy02:34

Empathy

10.2K
Some researchers suggest that altruism operates on empathy. Empathy is the capacity to understand another person’s perspective, to feel what he or she feels. An empathetic person makes an emotional connection with others and feels compelled to help (Batson, 1991). Empathy can be expressed in several ways, including cognitive, affective, and motor. 
10.2K
Bonanno's Theory of Grieving01:17

Bonanno's Theory of Grieving

1.3K
Grieving is a complex psychological and emotional process that varies significantly among individuals. George Bonanno's research on bereavement identified four distinct patterns of grieving, offering a nuanced understanding of how people cope with significant loss, such as the death of a spouse, over extended periods. These patterns — resilience, recovery, chronic dysfunction, and delayed grief — highlight the diversity in emotional responses and adaptive mechanisms.
Resilience
1.3K
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

14.6K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
14.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Family History and Solar Insolation in Bipolar I Disorder.

Acta psychiatrica Scandinavica·2026
Same author

Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study.

bioRxiv : the preprint server for biology·2025
Same author

Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study.

Brain, behavior, & immunity - health·2025
Same author

Long-term remissions with Gilteritinib in early relapse after allogeneic stem cell transplantation of FLT3/NPM1 mutated acute myeloid leukemia.

Blood cell therapy·2024
Same author

Multiplexed high-throughput immune cell imaging in patients with high-risk triple negative early breast cancer: Analysis from the International Breast Cancer Study Group (IBCSG) Trial 22-00.

European journal of cancer (Oxford, England : 1990)·2024
Same author

Radioimmunotherapy versus autologous hematopoietic stem cell transplantation in relapsed/refractory follicular lymphoma: a Fondazione Italiana Linfomi multicenter, randomized, phase III trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2023
Same journal

Gating effects of a Cav2.3 calcium channel variant linked to developmental and epileptic encephalopathy.

Neuroscience·2026
Same journal

Identification of polyamine metabolism-related gene signatures for prognostic and immunological stratification in glioma.

Neuroscience·2026
Same journal

Age- and sex-dependent effects of single prolonged stress on behavioral, hematological, and oxidative stress parameters in C57BL/6J mice.

Neuroscience·2026
Same journal

Accelerated long-term forgetting and relevant biomarkers for early detection in preclinical Alzheimer's disease.

Neuroscience·2026
Same journal

Deciphering key factors contributing to age-related decline in visuomotor tracking through the manipulation of target refresh rate and gaze contingency.

Neuroscience·2026
Same journal

LPI alleviates Alzheimer's disease pathology via the GPR55 receptor.

Neuroscience·2026
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli
09:16

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Published on: April 5, 2019

11.7K

Different contexts, different pains, different experiences.

E Carlino1, F Benedetti2

  • 1University of Turin Medical School, Neuroscience Department, Turin, Italy.

Neuroscience
|February 2, 2016
PubMed
Summary
This summary is machine-generated.

Psychosocial context significantly alters pain perception and experience. Positive contexts can relieve pain via neurochemical pathways, while negative contexts can worsen it.

Keywords:
analgesiacontextnoceboplaceboreward

More Related Videos

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
09:00

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

4.7K
Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

21.5K

Related Experiment Videos

Last Updated: Mar 26, 2026

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli
09:16

Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

Published on: April 5, 2019

11.7K
Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
09:00

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

4.7K
Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

21.5K

Area of Science:

  • Neuroscience
  • Psychology
  • Pain Research

Background:

  • Pain perception is highly subjective and context-dependent.
  • Placebo and nocebo effects highlight the influence of psychosocial factors on pain.

Purpose of the Study:

  • To review the impact of different contexts on pain perception.
  • To explore the underlying neurobiological mechanisms of context-pain interactions.

Main Methods:

  • Literature review focusing on studies investigating context and pain.
  • Analysis of neurobiological systems involved in pain modulation by context.

Main Results:

  • Positive contexts activate pain-relieving systems (opioids, cannabinoids, dopamine).
  • Negative contexts can exacerbate pain via systems like cholecystokinin and deactivation of opioids/dopamine.
  • Therapeutic effects are diminished when interventions are unknown to patients.

Conclusions:

  • Contextual factors profoundly modulate pain experience through specific neurobiological pathways.
  • Understanding these interactions is crucial for advancing pain research and clinical practice.