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Analogs of 1α,25-Dihydroxyvitamin D₃ in Clinical Use
Hector F DeLuca1, Lori A Plum1
1Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Abstract:
Biologically active metabolites of vitamin D that have been successfully developed for the clinical market are described. Their properties that resulted in their success in the clinic are also provided. Precursors of the metabolically active 1α,25-dihydroxyvitamin D have been prepared and successfully marketed not only for renal failure patients but also for a variety of patients having metabolic bone disorders. Finally, successful analogs of 1α,25-dihydroxyvitamin D in use in the clinic worldwide are presented including properties that have contributed to their success.
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