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Role of Skin in Vitamin D Synthesis01:23

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Related Experiment Video

Updated: Mar 26, 2026

High Efficiency Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes and Characterization by Flow Cytometry
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Vitamin D and Cardiac Differentiation.

Irene M Kim1, Keith C Norris2, Jorge N Artaza3

  • 1Department of Health & Life Sciences, Charles R. Drew University of Medicine and Science, Los Angeles, California, USA.

Vitamins and Hormones
|February 2, 2016
PubMed
Summary
This summary is machine-generated.

Vitamin D

Keywords:
CalcitriolCardiovascular diseaseCasein kinase-1-α1VDRWnt11

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Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Cell Biology

Background:

  • Vitamin D metabolite calcitriol (1,25-dihydroxycholecalciferol or 1,25-D3) regulates heart structure and function.
  • Vitamin D deficiency is linked to cardiovascular disease (CVD).
  • Calcitriol influences CVD-related signaling pathways, notably the Wnt pathway.

Purpose of the Study:

  • To characterize calcitriol's role in cardiac differentiation.
  • To investigate calcitriol's effects on cardiomyocyte Wnt11 signaling.

Main Methods:

  • Studied calcitriol's effects on cultured cardiomyocyte cells.
  • Examined calcitriol's impact on Wnt11 signaling pathways.

Main Results:

  • Calcitriol inhibited cardiomyocyte proliferation without inducing apoptosis.
  • Promoted cardiomyotube formation and upregulated noncanonical Wnt11 expression.
  • Downregulated canonical Wnt signaling pathway regulators.

Conclusions:

  • Vitamin D promotes cardiac differentiation via Wnt pathway modulation.
  • Upregulation of Wnt11 and downregulation of canonical Wnt signaling are key mechanisms.
  • Further research may improve CVD prevention and treatment, especially post-infarction remodeling.