Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

983
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
983
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes and Cost-Effectiveness of an Interdisciplinary Clinic for Functional Neurologic Disorders.

Neurology. Clinical practice·2026
Same author

The long reach of childhood income inequality: a multinational twin study of gene-environment interplay on adult depressive symptoms.

Psychological medicine·2026
Same author

Ultra-rare variants in LAMA2 are risk factors for frontotemporal dementia and motor neuron disease.

Human molecular genetics·2026
Same author

Disability, distress and delayed access to care in functional neurological disorder: cross-sectional study from an Australian tertiary clinic.

BJPsych open·2026
Same author

Subjective Sleep Traits and Cognition Across Mid- to Late-Adulthood: A Cross-Sectional Study of Gene-Environment Interplay.

Sleep·2026
Same author

Evaluating a Genome-Wide Polygenic Score for Handgrip Strength and its Interplay with Leisure-Time Physical Activity Across the IGEMS Twin Cohorts.

Medicine and science in sports and exercise·2026

Related Experiment Video

Updated: Mar 26, 2026

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
09:29

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

9.0K

Gene expression in the aging human brain: an overview.

Adith Mohan1, Karen A Mather, Anbupalam Thalamuthu

  • 1aCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW AustraliabNeuropsychiatric Institute, Prince of Wales Hospital, SydneycDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia.

Current Opinion in Psychiatry
|February 2, 2016
PubMed
Summary
This summary is machine-generated.

Gene expression changes in the aging human brain reveal pathways linked to neuroinflammation and cognitive decline. Understanding these genetic shifts offers hope for interventions against age-related brain diseases.

More Related Videos

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

4.2K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.5K

Related Experiment Videos

Last Updated: Mar 26, 2026

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
09:29

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

9.0K
Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

4.2K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.5K

Area of Science:

  • Neuroscience
  • Genetics
  • Aging Research

Background:

  • Human brain aging involves complex molecular changes.
  • Gene expression profiling offers insights into aging processes.
  • Understanding these changes is crucial for neurodegenerative disease research.

Purpose of the Study:

  • To summarize recent advancements in studying gene expression during human brain aging.
  • To highlight key findings regarding genetic pathways and their role in brain health and disease.

Main Methods:

  • Review of recent studies on gene expression in the aging human brain.
  • Analysis of differentially expressed genes (transcripts).
  • Investigation of pre- and post-transcriptional regulators, including noncoding RNAs.

Main Results:

  • Upregulation of genes related to neuroinflammation and immune activation in aging brains.
  • Identification of cellular ionic dyshomeostasis and synaptic efficacy decline.
  • Discovery of protective genetic responses that influence health trajectories.
  • Growing interest in noncoding RNAs as mediators of aging phenotypes.

Conclusions:

  • Gene expression studies illuminate cellular mechanisms of cognitive aging, disease risk, and resilience.
  • These findings open new avenues for early intervention in age-related neurodegenerative diseases.
  • Potential for developing novel disease-modifying therapies for aging brains.