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The developmental origins and lineage contributions of endocardial endothelium

Atsushi Nakano1, Haruko Nakano1, Kelly A Smith2

  • 1Department of Molecular Cell and Developmental Biology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA.

Biochimica Et Biophysica Acta
|February 2, 2016
PubMed

Insights

Endocardial development is more complex than previously thought. Recent studies reveal endocardium

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Cardiovascular Research

Background:

  • Endocardial development is a complex process involving cell fate decisions and coordination with other embryonic lineages.
  • Historically, endocardial contributions were primarily studied within the heart, focusing on myocardial lining and valve formation.
  • Recent research has expanded the understanding of endocardial lineage potential beyond the heart.

Purpose of the Study:

  • To review the expanding knowledge of endocardial fate potential.
  • To highlight recent studies elucidating the broader lineage capabilities of developing endocardium.

Main Methods:

  • Review of recent scientific literature across various species and model systems.
  • Analysis of studies investigating endocardial cell fate commitment and lineage tracing.

Main Results:

  • Endocardium contributes to more than just heart structures.
  • Evidence shows endocardium can give rise to cardiac vasculature, blood cells, fibroblasts, and cardiomyocytes.
  • This expanded potential is observed across diverse model systems.

Conclusions:

  • The developmental potential of endocardium is significantly broader than previously recognized.
  • Endocardial cells represent a versatile progenitor population with implications for cardiovascular and hematological development.
  • Further research is warranted to fully understand the mechanisms and therapeutic potential of endocardial plasticity.

Keywords:
CardiovascularDirected differentiationHematopoiesisHuman pluripotent stem cells, cardiacLineage tracing

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