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Growth hormone in the eye: A comparative update.

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The eye produces and responds to growth hormone (GH) in various species, including fish, amphibians, birds, and mammals. This review examines recent findings on ocular GH production and action.

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Area of Science:

  • Comparative physiology
  • Endocrinology
  • Ocular biology

Background:

  • The eye has been identified as an extrapituitary site for growth hormone (GH) production and action.
  • Previous comparative studies have confirmed this phenomenon across diverse vertebrate classes.

Purpose of the Study:

  • To review and synthesize recent literature on ocular growth hormone (GH) physiology.
  • To present original data concerning GH production and action within the eye.

Main Methods:

  • Literature review of recent studies on ocular GH.
  • Inclusion of original research data on GH in the eye.

Main Results:

  • The eye serves as a significant site for both the synthesis and reception of growth hormone (GH).
  • Evidence supports GH's role in ocular tissues across fish, amphibians, birds, and mammals.

Conclusions:

  • The eye's role as an extrapituitary GH site is further substantiated by recent research.
  • Understanding ocular GH physiology has implications for comparative endocrinology and vision research.