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Related Experiment Videos

Seven fatalities associated with ethylphenidate.

P D Maskell1, P R Smith2, R Cole2

  • 1Department of Chemical and Forensic Sciences, School of Applied Sciences. University of Huddersfield, Huddersfield, HD1 3DH, UK.

Forensic Science International
|February 2, 2016
PubMed
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Ethylphenidate, a stimulant drug, is increasingly detected in post-mortem cases. Analysis of seven cases reveals its presence alongside other substances, complicating cause of death determination.

Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry
  • Pharmacology

Background:

  • Ethylphenidate is a stimulant novel psychoactive substance and an analogue of methylphenidate.
  • While methylphenidate is prescribed for ADHD, ethylphenidate is increasingly being abused.
  • Limited data exists on ethylphenidate's contribution to mortality.

Observation:

  • This study analyzed seven post-mortem cases (February 2013-January 2015) where ethylphenidate was detected using LC-MS/MS.
  • Individuals were male, aged 23-49 years (median 25).
  • Ethylphenidate concentrations ranged from 0.026 to 2.18 mg/L in femoral blood.

Findings:

  • Ethylphenidate was the sole drug detected in only one case.
  • In the other six cases, ethylphenidate was found with benzodiazepines, heroin, methadone, antipsychotics, or other novel psychoactive compounds.
Keywords:
Case studyEthylphenidateMethylphenidatePoisoningPost-mortem

Related Experiment Videos

  • Ethylphenidate toxicity was the sole cause of death in one case; two deaths were by hanging, and four by mixed drug toxicity.

    • Implications:

    • These findings highlight the complex role of ethylphenidate in polydrug toxicity cases.
    • The data provides crucial reference concentrations for interpreting post-mortem ethylphenidate levels in forensic investigations.
    • Further research is needed to fully understand the toxicological profile and clinical significance of ethylphenidate abuse.