Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comparison of non-absorbable polymeric clips and staplers for laparoscopic appendiceal stump closure: analysis of 618 adult patients.

Langenbeck's archives of surgery·2019
Same author

Corrigendum to "Single ingestion of di-(2-propylheptyl) phthalate (DPHP) by male volunteers: DPHP in blood and its metabolites in blood and urine" [Toxicol. Lett. 294 (2018) 105-115].

Toxicology letters·2018
Same author

Single ingestion of di-(2-propylheptyl) phthalate (DPHP) by male volunteers: DPHP in blood and its metabolites in blood and urine.

Toxicology letters·2018
Same author

Review of data on the dermal penetration of mineral oils and waxes used in cosmetic applications.

Toxicology letters·2017
Same author

Impurity profiling of liothyronine sodium by means of reversed phase HPLC, high resolution mass spectrometry, on-line H/D exchange and UV/Vis absorption.

Journal of pharmaceutical and biomedical analysis·2017
Same author

Levothyroxine sodium revisited: A wholistic structural elucidation approach of new impurities via HPLC-HRMS/MS, on-line H/D exchange, NMR spectroscopy and chemical synthesis.

Journal of pharmaceutical and biomedical analysis·2016

Related Experiment Video

Updated: Mar 26, 2026

Ultrafast Time-resolved Near-IR Stimulated Raman Measurements of Functional π-conjugate Systems
09:57

Ultrafast Time-resolved Near-IR Stimulated Raman Measurements of Functional π-conjugate Systems

Published on: February 10, 2020

7.7K

Rationale for the update of the European Pharmacopoeia general chapter 2.2.48. Raman spectroscopy.

I R Lynch1, W Schuh2, W Kessler3

  • 1GSK, United Kingdom.

Pharmeuropa Bio & Scientific Notes
|February 3, 2016
PubMed
Summary

New Raman spectroscopy standards enhance material identification. This update, driven by inter-laboratory studies, refines Process Analytical Technologies (PAT) applications for greater accuracy.

Keywords:
PATRaman Spectroscopyinstrument verificationwavenumber tolerance

More Related Videos

A Novel Technique for Raman Analysis of Highly Radioactive Samples Using Any Standard Micro-Raman Spectrometer
07:52

A Novel Technique for Raman Analysis of Highly Radioactive Samples Using Any Standard Micro-Raman Spectrometer

Published on: April 12, 2017

13.5K
Raman and IR Spectroelectrochemical Methods as Tools to Analyze Conjugated Organic Compounds
09:11

Raman and IR Spectroelectrochemical Methods as Tools to Analyze Conjugated Organic Compounds

Published on: October 12, 2018

19.1K

Related Experiment Videos

Last Updated: Mar 26, 2026

Ultrafast Time-resolved Near-IR Stimulated Raman Measurements of Functional π-conjugate Systems
09:57

Ultrafast Time-resolved Near-IR Stimulated Raman Measurements of Functional π-conjugate Systems

Published on: February 10, 2020

7.7K
A Novel Technique for Raman Analysis of Highly Radioactive Samples Using Any Standard Micro-Raman Spectrometer
07:52

A Novel Technique for Raman Analysis of Highly Radioactive Samples Using Any Standard Micro-Raman Spectrometer

Published on: April 12, 2017

13.5K
Raman and IR Spectroelectrochemical Methods as Tools to Analyze Conjugated Organic Compounds
09:11

Raman and IR Spectroelectrochemical Methods as Tools to Analyze Conjugated Organic Compounds

Published on: October 12, 2018

19.1K

Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Process Analytical Technologies (PAT)

Background:

  • Raman spectroscopy is crucial for material identification in labs and Process Analytical Technologies (PAT).
  • Existing general chapters require updates due to the diverse range of available Raman technologies.
  • The PAT Working Party identified a need for revised standards.

Purpose of the Study:

  • To explain the rationale for new wavenumber scale standards and peak position tolerances in Raman spectroscopy.
  • To present findings from a multi-site, multi-instrument, inter-laboratory study.
  • To discuss specific results obtained using Raman microscopy with multi-point calibration.

Main Methods:

  • Conducting a multi-site, multi-instrument, inter-laboratory study of Raman spectroscopy standards.
  • Analyzing data from various instruments, including Raman microscopes.
  • Implementing multi-point calibration techniques.

Main Results:

  • Establishment of new, validated wavenumber scale standards.
  • Defined peak position tolerances based on extensive inter-laboratory data.
  • Demonstrated performance of standards with Raman microscopy applications.

Conclusions:

  • The updated standards provide a more robust framework for Raman spectroscopy.
  • Revised tolerances ensure greater accuracy and reliability in material characterization.
  • These advancements are critical for the effective implementation of PAT.