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[Refractory anasarca].

J J Gonvers1, F Delacrétaz

  • 1Département de médecine interne, Centre hospitalier universitaire vaudois, Lausanne.

Schweizerische Medizinische Wochenschrift
|October 21, 1989
PubMed
Summary
This summary is machine-generated.

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A retroperitoneal lymphoma caused chylous ascites and pleural effusion in a patient with a tibial fracture. Despite chemotherapy, the patient developed complications including peritonitis and septic shock, leading to death. Autopsy confirmed widespread lymphoma.

Area of Science:

  • Oncology
  • Gastroenterology
  • Cardiology

Background:

  • A 68-year-old male with a tibial fracture presented with leg edema, ascites, and pleural effusions.
  • Initial treatment included digitalis and diuretics, but symptoms worsened.

Observation:

  • The patient developed epigastric pain, vomiting, and ECG changes suggestive of myocardial infarction.
  • Imaging revealed a retroperitoneal mass causing vena cava compression and bilateral hydronephrosis.
  • Analysis of pleural and abdominal fluid showed milky liquid consistent with chylous effusion and ascites.

Findings:

  • Histopathology confirmed a low-grade Non-Hodgkin B-cell malignant lymphoma.
  • Chemotherapy with prednisone, vincristine, and cyclophosphamide was initiated.
  • The patient experienced complications including peritonitis, phlegmonous cholecystitis, and a perforated colon.

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Implications:

  • This case highlights a rare presentation of retroperitoneal lymphoma leading to chylous ascites and cardiac events.
  • The study underscores the importance of considering malignancy in cases of unexplained chylous effusions.
  • Despite aggressive treatment, the patient's advanced disease and complications resulted in a fatal outcome.