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Related Concept Videos

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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
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Abnormal Functional Connectivity Density in Post-traumatic Stress Disorder.

Youxue Zhang1, Bing Xie2, Heng Chen1

  • 1Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, People's Republic of China.

Brain Topography
|February 3, 2016
PubMed
Summary
This summary is machine-generated.

Post-traumatic stress disorder (PTSD) disrupts long-range brain connections, particularly in the fronto-parietal network. This study reveals altered functional connectivity density in PTSD patients, impacting attention and visual processing.

Keywords:
Dorsolateral prefrontal cortexFunctional connectivity densityPost-traumatic stress disorder

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Post-traumatic stress disorder (PTSD) is linked to abnormal brain region integration.
  • Previous neuroimaging studies suggest functional connectivity alterations in PTSD.

Purpose of the Study:

  • To investigate aberrant functional connectivity (FC) in PTSD using functional connectivity density (FCD) mapping.
  • To explore differences in short- and long-range FCD between PTSD patients and healthy controls (HCs).

Main Methods:

  • Utilized resting-state functional magnetic resonance imaging (fMRI).
  • Applied functional connectivity density (FCD) mapping, a novel voxel-wise, graph theory-based approach.
  • Conducted seed-based FC analysis focusing on the left dorsolateral prefrontal cortex (DLPFC).

Main Results:

  • PTSD patients exhibited significantly increased long-range FCD in the left DLPFC compared to HCs.
  • No significant abnormalities in short-range FCD were detected in PTSD patients.
  • Seed-based analysis revealed increased connectivity between the left DLPFC and the left superior parietal lobe and visual cortex in PTSD patients.

Conclusions:

  • PTSD is associated with disrupted intrinsic long-range functional connections within the fronto-parietal network.
  • Altered connectivity in the visual cortex of PTSD patients may affect visual information processing.
  • Findings highlight the role of fronto-parietal and visual network disruptions in PTSD pathophysiology, potentially impacting attention control.