Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Directing cell division during development.

P H O'Farrell1, B A Edgar, D Lakich

  • 1Department of Biochemistry and Biophysics, School of Medicine, University of California, San Francisco 94143.

Science (New York, N.Y.)
|November 3, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AF-1 a novel regulator of the redox equilibrium during aging.

Free radical biology & medicine·2015
Same author

Using the Fly-FUCCI System for the Live Analysis of Cell Cycle Dynamics in Cultured Drosophila Cells.

Methods in molecular biology (Clifton, N.J.)·2015
Same author

FUCCI sensors: powerful new tools for analysis of cell proliferation.

Wiley interdisciplinary reviews. Developmental biology·2015
Same author

Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine.

Oncogene·2014
Same author

Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110.

Cell death & disease·2013
Same author

Genomic binding and transcriptional regulation by the Drosophila Myc and Mnt transcription factors.

Cold Spring Harbor symposia on quantitative biology·2006

Cell division timing in embryos shifts from maternal control using cyclin to zygotic control involving string gene transcription, ensuring precise developmental patterning.

Area of Science:

  • Developmental biology
  • Cell cycle regulation
  • Molecular embryology

Background:

  • Embryogenesis relies on precisely timed cell divisions orchestrated by a universal mitotic trigger.
  • Early embryonic cell divisions are governed by maternal factors, while later stages transition to zygotic control.
  • Cyclin accumulation and degradation regulate early cell divisions in organisms like Xenopus.

Purpose of the Study:

  • To investigate the transition in cell division control mechanisms during embryogenesis.
  • To understand the roles of maternal factors versus zygotic gene products in timing cell divisions.
  • To elucidate the regulatory switch from cyclin-dependent timing to transcription-dependent timing.

Main Methods:

  • Comparative analysis of cell cycle control in different embryonic stages.

Related Experiment Videos

  • Study of gene product roles (cyclin, string) in cell division timing.
  • Investigation of maternal versus zygotic gene expression control.

    • Main Results:

    • Early embryonic cell divisions are timed by maternal cyclin accumulation and degradation.
    • Later embryonic divisions are controlled by zygotic transcription, specifically the 'string' gene.
    • The transition to zygotic control redefines cell division timing and patterning, with cyclin no longer being rate-limiting.

    Conclusions:

    • The control of the mitotic trigger evolves during embryogenesis.
    • Zygotic transcription, exemplified by the 'string' gene, becomes crucial for patterned cell divisions after the maternal-to-zygotic transition.
    • This regulatory shift ensures accurate developmental progression.