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Single Nanoparticle Translocation Through Chemically Modified Solid Nanopore.

Shengwei Tan1, Lei Wang2, Hang Liu3

  • 1State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Sipailou Campus, No. 2, Sipailou, Nanjing, 210096, People's Republic of China. sw-tan@seu.edu.cn.

Nanoscale Research Letters
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Summary
This summary is machine-generated.

This study demonstrates how functionalizing silicon nitride nanopores enhances nanoparticle detection. Surface modification allows for controlled capture and analysis of negatively charged nanoparticles, improving signal clarity for potential applications like gene sequencing.

Keywords:
Chemical surface modificationsNanoporePolystyrene nanoparticles

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Analytical Chemistry

Background:

  • Nanopore sensors offer high-throughput, low-cost detection of single nanoparticles.
  • Surface properties of nanopores significantly influence particle interaction and detection.
  • Controlling nanoparticle translocation is crucial for signal resolution.

Purpose of the Study:

  • To fabricate and functionalize silicon nitride nanopores for enhanced nanoparticle detection.
  • To investigate the electrophoretic translocation of polystyrene nanoparticles through functionalized nanopores.
  • To explore the impact of surface functionalization and solution pH on nanoparticle transport dynamics.

Main Methods:

  • Fabrication of silicon nitride nanopores using focused ion beam (FIB).
  • Surface functionalization with 3-aminopropyltriethoxysilane to alter surface charge.
  • Electrophoretic translocation measurements using the Coulter counter principle, recording time-dependent nanopore current.
  • Systematic variation of solution pH (5.4, 7.0, 10.0) and biased voltage.

Main Results:

  • Functionalized nanopores exhibited attraction to negatively charged nanoparticles, slowing translocation.
  • A linear relationship was observed between current drop and biased voltage.
  • An exponential decay function described the relationship between translocation duration and biased voltage.
  • Solution pH influenced the interaction between the functionalized nanopore wall and nanoparticles.

Conclusions:

  • Surface functionalization is an effective strategy to tune nanopore properties for selective particle detection.
  • The developed method provides a clear and deterministic signal for nanoparticle analysis.
  • This approach holds promise for applications in fields such as gene sequencing.