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Coronary leukocyte activation in relation to progression of coronary artery disease

Marijke A de Vries1, Arash Alipour2, Erwin Birnie3

  • 1Department of Internal Medicine, Centre for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis, Rotterdam, P.O. Box 10900, 3004 BA, The Netherlands. m.devries@franciscus.nl.

Frontiers of Medicine
|February 3, 2016
PubMed

Insights

Leukocyte activation markers in coronary arteries do not predict coronary artery disease (CAD) progression. Studies show no association between monocyte CD11b, neutrophil CD11b, CD66b, and myeloperoxidase levels and future cardiovascular events.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Atherosclerosis Research

Background:

  • Leukocyte activation is implicated in atherogenesis.
  • Limited in vivo evidence exists for its role in atherosclerosis progression.
  • Coronary artery disease (CAD) progression requires reliable predictive markers.

Purpose of the Study:

  • To assess the predictive value of leukocyte activation markers in coronary circulation for CAD progression.
  • To investigate the association between monocyte and neutrophil markers and adverse cardiovascular outcomes.

Main Methods:

  • Flow cytometry was used to measure monocyte CD11b, neutrophil CD11b, CD66b expression, and intracellular myeloperoxidase (MPO) in coronary artery blood.
  • Patients undergoing coronary angiography were included.
  • Primary outcome: fatal/nonfatal myocardial infarction or arterial vascular intervention for unstable angina.

Main Results:

  • In 99 subjects (70 with CAD), 13% experienced CAD progression over a median follow-up of 2242 days.
  • Coronary monocyte CD11b, neutrophil CD11b and CD66b expression, and intracellular MPO were not associated with CAD progression.
  • No predictive value was found for these specific leukocyte activation markers.

Conclusions:

  • Coronary leukocyte activation markers, including monocyte CD11b, neutrophil CD11b/CD66b, and intracellular MPO, do not predict the risk of coronary artery disease progression.
  • These findings suggest that these markers are not useful for risk stratification in patients with established CAD.

Keywords:
coronary artery diseaseinflammationintegrinleukocyte activamyeloperoxidase

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