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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Updated: Mar 26, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Methods to Study Metastasis in Genetically Modified Mice.

Farhia Kabeer¹, Levi J Beverly², Guillaume Darrasse-Jèze³

¹Institut de Recherches Cliniques de Montréal, Montréal, Quebec H2W 1R7, Canada; Department of Medicine, Experimental Medicine Division, McGill University, Montréal, Quebec H3A 1A3, Canada;

Cold Spring Harbor Protocols

|February 3, 2016

Summary

This summary is machine-generated.

Genetically modified mouse models offer a complementary approach to xenotransplantation for studying cancer metastasis. These models enable the investigation of tumor spread as a systemic disease, providing insights into the natural history of cancer.

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Area of Science:

Oncology
Genetics
Animal Models

Background:

Metastasis research often relies on xenotransplantation of cell lines in immunodeficient mice.
This
tumor-centric" approach focuses on cell-autonomous determinants of tumor dissemination.
It uses the animal body as a
sophisticated Petri dish" for tumor growth.

Purpose of the Study:

To describe methodological approaches for studying cancer metastasis in genetically modified mice.
To highlight the utility of transgenic and gene knockout models.
To focus on models with regulated expression of human oncogenes in breast cancer.

Main Methods:

Utilizing transgenic and gene knockout mouse models of cancer.
Studying tumor spread as a systemic disease.
Employing animals with regulated expression of human oncogenes, particularly in breast cancer.

Main Results:

Genetically modified mouse models provide a complementary approach to xenotransplantation.
These models allow for the study of tumor spread as a systemic process.
They offer insights into the natural history of cancer development and dissemination.

Conclusions:

Genetically modified mouse models are valuable tools for understanding cancer metastasis.
They offer a more holistic view of tumor spread compared to traditional xenotransplantation methods.
These models are crucial for studying cancer as a systemic disease.