Related Experiment Video
Updated: Mar 26, 2026
Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
Published on: February 17, 2023
Progression in children with intestinal failure at a referral hospital in Medellín, Colombia
M M Contreras-Ramírez1, A Giraldo-Villa2, C Henao-Roldan3
1Grupo de Soporte Nutricional Pediátrico, Hospital Pablo Tobón Uribe, Medellín, Colombia.
Insights
Pediatric intestinal failure management is complex. Early recognition and nutritional support are crucial for achieving intestinal autonomy and improving survival rates in children.
Area of Science:
- Pediatric Gastroenterology
- Intestinal Rehabilitation
- Clinical Outcomes Research
Background:
- Intestinal failure (IF) significantly impairs nutrition and hydration due to reduced intestinal function.
- Effective management strategies aim to enhance intestinal autonomy, quality of life, and survival for IF patients.
Purpose of the Study:
- To characterize clinical features of pediatric IF.
- To assess disease progression regarding intestinal autonomy and survival in children with IF.
Main Methods:
- Retrospective analysis of 33 pediatric patients with IF hospitalized between 2005-2013.
- Evaluation of patient characteristics at admission.
- Estimation of intestinal autonomy achievement and survival rates.
Main Results:
- Median age at admission was 2 months; 54.5% were boys.
- Intestinal autonomy achieved in 69.7% of patients (median 148 days), faster with ileocecal valve preservation (63 days).
- Survival rate was 91% at a median follow-up of 281 days.
Conclusions:
- Managing pediatric IF requires complex medical care, emphasizing nutritional support and close monitoring.
- Long-term outcomes depend on prompt identification and management of complications associated with IF.
Background:
Patients with intestinal failure are unable to maintain adequate nutrition and hydration due to a reduction in the functional area of the intestine. Different strategies have the potential to benefit these patients by promoting intestinal autonomy, enhancing quality of life, and increasing survival.
Aims:
To describe the clinical characteristics of children with intestinal failure and disease progression in terms of intestinal autonomy and survival.
Materials And Methods:
A retrospective study was conducted, evaluating 33 pediatric patients with intestinal failure that were hospitalized within the time frame of December 2005 and December 2013 at a tertiary care referral center. Patient characteristics were described upon hospital admission, estimating the probability of achieving intestinal autonomy and calculating the survival rate.
Results:
Patient median age upon hospital admission was 2 months (interquartile range [IQR]: 1-4 months) and 54.5% of the patients were boys. Intestinal autonomy was achieved in 69.7% of the cases with a median time of 148 days (IQR: 63 - 431 days), which decreased to 63 days in patients with a spared ileocecal valve. Survival was 91% during a median follow-up of 281 days (IQR: 161 - 772 days).
Conclusions:
Medical management of patients with intestinal failure is complex. Nutritional support and continuous monitoring are of the utmost importance and long-term morbidity and mortality depends on the early recognition and management of the associated complications.
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:15Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...