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Updated: Mar 26, 2026

Purification of Hepatocytes and Sinusoidal Endothelial Cells from Mouse Liver Perfusion
Published on: February 12, 2018
Non-ionic macroporous polystyrene adsorbents for removal of serum toxins in liver failure by hemoperfusion
Jian Chen1, Wenyan Han1, Rui Su2
1a The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences , Nankai University , Tianjin , China.
Abstract:
Strong base anion exchange resin (e.g., BL-300) is currently used to eliminate bilirubin from blood in clinical hemoperfusion. However, there is a potential weakness of the resin to remove heparin and activation of coagulation. To overcome this weakness, we prepared a novel non-ionic macroporous polystyrene adsorbent (SZ-9) with rich mesopores and high surface area by suspension polymerization. Test results indicated that SZ-9 performed better adsorption capacity for bilirubin than BL-300. In addition, better blood compatibility was observed during whole blood hemoperfusion. Therefore, adsorbent SZ-9 might be an efficient alternative to anion exchange resin for the removal of bilirubin in hemoperfusion.
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Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
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