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Updated: Mar 26, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Opioid substitution therapy: Lowering the treatment thresholds

Georgios Kourounis1, Brian David Wensley Richards1, Evdokia Kyprianou2

  • 1St George's University of London, Medical School at the University of Nicosia, Agiou Nikolaou Street 93, Engomi, 2408 Nicosia, Cyprus; Department of Addiction Psychiatry, Athalassa Psychiatric Hospital, Cyprus Mental Health Services, Leoforos Lemesou 199/2, 1452 Nicosia, Cyprus.

Drug and Alcohol Dependence
|February 3, 2016
PubMed
Summary

Opioid substitution therapy (OST) is effective for opioid use disorders. Low threshold OST designs, which reduce patient barriers and offer personalized care, show better treatment outcomes than high threshold approaches.

Keywords:
AddictionBuprenorphineCyprusDrugsHarm reductionHeroinMethadoneOSTOpioidPolicySubstitutionThreshold

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