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Targeting the IL-33/IL-13 Axis for Respiratory Viral Infections

Chantal Donovan1, Jane E Bourke1, Ross Vlahos2

  • 1Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Victoria, Australia; Lung Health Research Centre, Department of Pharmacology and Therapeutics, University of Melbourne, Victoria, Australia.

Trends in Pharmacological Sciences
|February 3, 2016
PubMed

Insights

Viral infections worsen lung diseases like asthma and COPD. Targeting the interleukin-33/interleukin-13 (IL-33/IL-13) axis offers a promising new therapy for virus-induced lung disease exacerbations.

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Virology

Background:

  • Lung diseases, including asthma and COPD, affect millions globally.
  • Viral infections frequently trigger exacerbations, diminishing patient quality of life.
  • Current treatments for virus-induced lung disease face challenges like antiviral resistance and vaccine specificity.

Purpose of the Study:

  • To review current evidence on the role of the IL-33/IL-13 axis in virus-induced lung disease.
  • To explore the potential of targeting this axis as a novel therapeutic strategy.

Main Methods:

  • Review of human clinical data.
  • Analysis of preclinical animal models.

Main Results:

  • Evidence implicates the IL-33/IL-13 signaling pathway in the pathogenesis of virus-induced lung disease.
  • This axis plays a significant role in exacerbations of conditions like asthma and COPD.

Conclusions:

  • The IL-33/IL-13 axis represents a potential therapeutic target for managing virus-induced lung disease exacerbations.
  • Targeting this pathway could offer an alternative to current treatments with limitations in efficacy and resistance.
Keywords:
acute exacerbationinterleukin-13interleukin-33viral infection

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