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Bidirectional Transfer of Raltegravir in an Ex Vivo Human Cotyledon Perfusion Model
Cécile Vinot1, Jean-Marc Tréluyer2, Carole Giraud3
1EA 3620, Université Paris Descartes, Paris, France Unité de Recherche Clinique Cochin Necker/CIC 0901, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France Risk in Pregnancy University Department, Paris, France.
Abstract:
Placental transfer of the HIV integrase inhibitor raltegravir (RLT) was investigated in term human cotyledons in the maternal-to-fetal (n = 3) and fetal-to-maternal (n = 6) directions. In the maternal-to-fetal direction, the mean ± standard deviation (SD) fetal transfer rate (FTR) was 9.1% ± 1.4%, and the mean ± SD clearance index (IC), i.e., RLT FTR/antipyrine FTR, was 0.28 ± 0.05. In the fetal-to-maternal direction, the mean ± SD CI was 0.31 ± 0.09. Placental transfer of RLT was high in both directions.
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