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Interstitial changes in asthma-COPD overlap syndrome.

Sahoko Chiba¹, Kimitake Tsuchiya¹, Yoshihisa Nukui¹

¹Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

The Clinical Respiratory Journal

|February 3, 2016

Summary

Asthma-COPD overlap syndrome (ACOS) patients with interstitial lung changes were found to be heavier smokers with thicker airway walls. These findings highlight potential links between smoking, interstitial changes, and ACOS severity.

Keywords:

asthma-COPD overlap syndrome - asthma - chronic obstructive pulmonary disease - interstitial lung diseases

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

Pulmonology
Radiology
Internal Medicine

Background:

Asthma-COPD overlap syndrome (ACOS) involves the co-occurrence of asthma and COPD.
Cigarette smoking is a risk factor for ACOS and is linked to interstitial lung diseases (ILDs).
Subclinical ILDs are common in smokers, suggesting potential interstitial changes in ACOS.

Purpose of the Study:

To investigate the presence of interstitial changes in ACOS patients.
To characterize the clinical features of ACOS associated with interstitial changes.

Main Methods:

High-resolution computed tomography (HRCT) was used to assess interstitial lung changes in 30 ACOS patients.
Clinical data and airway wall thickness on HRCT were compared between ACOS patients with and without interstitial changes.

Main Results:

Interstitial changes were detected in 23.3% of ACOS patients via HRCT.
ACOS patients with interstitial changes had higher age, smoking amounts (pack-years), and thicker airway walls.
Fungal sensitization was more frequent in ACOS patients with interstitial changes.

Conclusions:

ACOS patients with interstitial changes are characterized by heavier smoking histories.
Thicker airway walls on HRCT are associated with interstitial changes in ACOS.
Interstitial lung changes may be an under-recognized feature in ACOS, particularly in smokers.