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Updated: Mar 26, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
Published on: October 25, 2015
Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development
Ann Hellström1, David Ley2, Ingrid Hansen-Pupp2
1Department of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Unlabelled:
Poor postnatal growth after preterm birth does not match the normal rapid growth in utero and is associated with preterm morbidities. Insulin-like growth factor 1 (IGF-1) axis is the major hormonal mediator of growth in utero, and levels of IGF-1 are often very low after preterm birth. We reviewed the role of IGF-1 in foetal development and the corresponding preterm perinatal period to highlight the potential clinical importance of IGF-1 deficiency in preterm morbidities.
Conclusion:
There is a rationale for clinical trials to evaluate the potential benefits of IGF-1 replacement in very preterm infants.
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