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Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
Published on: August 23, 2018
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Emerging Supramolecular Therapeutic Carriers Based on Host-Guest Interactions
Anis Abdul Karim1, Qingqing Dou1, Zibiao Li2
1Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, 08-03, Singapore, 138634, Singapore.
Chemistry, an Asian Journal
|February 3, 2016
Summary
Host-guest chemistry enables the creation of advanced supramolecular soft biomaterials for drug and gene delivery. These materials offer precise control over size and morphology for targeted therapeutic applications.
Area of Science:
- Supramolecular Chemistry
- Materials Science
- Biotechnology
Background:
- Host-guest chemistry offers precise control over molecular interactions.
- Supramolecular self-assemblies are crucial for developing advanced biomaterials.
- Non-covalent interactions facilitate rational design of delivery systems.
Purpose of the Study:
- To review recent developments in supramolecular soft biomaterials.
- To highlight applications in therapeutic agent delivery.
- To propose future directions combining host-guest chemistry and biological interface science.
Main Methods:
- Focus review of supramolecular self-assemblies via host-guest inclusion.
- Categorization of materials: nanoparticles, micelles, vesicles, hydrogels.
- Analysis of stimuli-responsive morphology transition materials.
Main Results:
- Supramolecular assemblies enable rational design of carrier vehicles.
- Diverse functional materials include nanoparticles, micelles, vesicles, and hydrogels.
- Applications span drug delivery, gene delivery, co-delivery, and targeted delivery.
Conclusions:
- Host-guest chemistry is pivotal for designing sophisticated biomaterials.
- These materials show significant promise for various therapeutic delivery systems.
- Integrating host-guest chemistry with biological interface science can yield multifunctional carriers.
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