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[Several recent advances in the significance and properties of interleukins]
1Wissenschaftsbereich Tierbiochemie, Karl-Marx-Universität Leipzig.
The interleukins play an important role as intensifying molecules in the activation of the immune system in infections and inflammation processes. Antigens are worked up by macrophages and B-lymphocytes, whereby partly develop particularly intensively antigen-effective compounds. The uptake of antigens in macrophages evokes the formation of interleukin 1 which has multivarious effects. The macrophages and the B-lymphocytes present the antigens worked up after uptake into the cell membrane to certain forms of T-lymphocytes which thus are stimulated to the formation of the interleukins 2 to 6. The interleukins 2 and 4 promote the increase of certain forms of T-lymphocytes and the formation of cytotoxically acting T-lymphocytes. The interleukin 3 is of importance for the increase of stem cells of the bone-marrow and for their differentiation. The interleukins 4, 5, and 6 promote the increase of certain B-lymphocytes. In the liver the interleukins 1 and 6 stimulate the formation of numerous proteins which have influence on inflammation processes.
The interleukins play an important role as intensifying molecules in the activation of the immune system in infections and inflammation processes. Antigens are worked up by macrophages and B-lymphocytes, whereby partly develop particularly intensively antigen-effective compounds. The uptake of antigens in macrophages evokes the formation of interleukin 1 which has multivarious effects. The macrophages and the B-lymphocytes present the antigens worked up after uptake into the cell membrane to certain forms of T-lymphocytes which thus are stimulated to the formation of the interleukins 2 to 6. The interleukins 2 and 4 promote the increase of certain forms of T-lymphocytes and the formation of cytotoxically acting T-lymphocytes. The interleukin 3 is of importance for the increase of stem cells of the bone-marrow and for their differentiation. The interleukins 4, 5, and 6 promote the increase of certain B-lymphocytes. In the liver the interleukins 1 and 6 stimulate the formation of numerous proteins which have influence on inflammation processes.