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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Related Experiment Video

Updated: Mar 26, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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The Current and Future Therapies for Human Osteosarcoma.

Joseph D Lamplot1, Sahitya Denduluri1, Jiaqiang Qin2

  • 1Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA.

Current Cancer Therapy Reviews
|February 3, 2016
PubMed
Summary

Osteosarcoma (OS) is a common bone cancer with poor prognosis, especially in metastatic cases. Novel therapies targeting molecular pathways are crucial for improving patient survival outcomes.

Keywords:
BMPBisphosphonatesIGFIGFBP5OS99limb-salvageosteosarcoma

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Area of Science:

  • Oncology
  • Orthopedic Oncology
  • Cancer Research

Background:

  • Osteosarcoma (OS) is the most frequent non-hematologic bone malignancy in children and adults.
  • It presents a poor prognosis due to high grade, chemotherapy resistance, and lung metastasis.
  • Despite advances, survival rates for metastatic OS have stagnated, highlighting the need for new treatments.

Purpose of the Study:

  • To review current Osteosarcoma therapies and clinical trials.
  • To discuss novel therapeutic targets and ongoing research for OS.
  • To provide an overview of the molecular pathways involved in OS.

Main Methods:

  • Literature review of current Osteosarcoma management.
  • Analysis of ongoing and completed Phase I, II, and III clinical trials for sarcoma therapies.
  • Examination of preclinical research on OS-directed therapeutics.

Main Results:

  • Current OS management combines chemotherapy and surgery, improving cure rates to 65-75%.
  • Phase I trials show objective responses in OS patients.
  • Novel drug delivery mechanisms are in Phase II and III trials.

Conclusions:

  • Advances in chemotherapy and surgery have plateaued, particularly for metastatic OS.
  • Understanding molecular pathways is key to developing effective OS therapies.
  • Further research and clinical trials are essential for improving patient survival in Osteosarcoma.