[Immunity indices during the vaccinal therapy of protracted forms of dysentery in children]

The results obtained in the study of the dynamics of systemic and local immunity characteristics in children with prolonged and chronic dysentery under the influence of vaccinal therapy are presented. The vaccine, containing soluble antigenic complexes isolated from Shigella sonnei cells by disintegration with hydroxylamine, was introduced intrarectally in doses of 2-4 mg. The course of treatment consisted of 5-6 administrations. The vaccinal therapy resulted in an increase in the level of immunoglobulins and the titer of specific antibodies, particularly IgA, in sera and fecal filtrates. These data coincided with an increase in the number of IgA-producing cells in bioptic samples of the mucous membrane of the large intestine. The vaccinal therapy contributed to the cessation of the release of bacteria in 82.5% of the patients.