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Updated: Mar 26, 2026

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

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Published on: April 16, 2019

Permeability imaging in pediatric brain tumors.

Sandi Lam¹, Yimo Lin¹, Peter C Warnke¹

¹1 Department of Neurosurgery, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA ; 2 Functional and Stereotactic Neurosurgery, Department of Surgery, University of Chicago, Chicago, Illinois, USA.

Translational Pediatrics

|February 3, 2016

Summary

Dynamic imaging techniques assess blood-brain barrier (BBB) permeability in pediatric central nervous system (CNS) tumors. This approach aids in diagnosing and managing brain tumors by analyzing contrast movement and applying pharmacokinetic models.

Keywords:

MRI Permeability imaging brain tumor imaging computed tomography (CT)pediatric brain tumor positron emission tomography (PET)

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Last Updated: Mar 26, 2026

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Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy

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Published on: May 3, 2019

Area of Science:

Neuroimaging
Pharmacokinetics
Pediatric Oncology

Background:

Traditional CT and MR imaging show brain pathology structure.
Dynamic imaging visualizes contrast movement across the blood-brain barrier (BBB).
BBB permeability analysis is crucial for pediatric central nervous system (CNS) tumors.

Purpose of the Study:

Review technical principles of four BBB permeability imaging modalities.
Compare advantages and disadvantages of different techniques.
Explore clinical applications of permeability imaging in pediatric CNS tumors.

Main Methods:

Review of PET, dynamic CT, dynamic T1-weighted contrast-enhanced MR, and dynamic T2-weighted susceptibility contrast MR.
Analysis of data derived from each imaging method.
Discussion of pharmacokinetic modeling for BBB permeability assessment.

Main Results:

Detailed description of data obtainable from each modality.
Comparison of strengths and weaknesses of PET, dynamic CT, and dynamic MR imaging.
Identification of potential pitfalls in data interpretation.

Conclusions:

Dynamic imaging and pharmacokinetic models offer insights into BBB permeability.
Applications include diagnosing tumor nature, predicting tumor behavior, and monitoring treatment response.
Permeability imaging supports the development of novel pediatric brain tumor therapies.