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Lin28 and let-7 in cell metabolism and cancer

Liem H Nguyen1, Hao Zhu1

  • 1Children's Research Institute, Departments of Pediatrics and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Translational Pediatrics
|February 3, 2016
PubMed

Insights

The Lin28 RNA-binding protein and let-7 microRNA pathway regulates cell metabolism. This pathway influences tissue repair and drives cancer development by altering cellular metabolism.

Area of Science:

  • Cellular metabolism
  • Developmental biology
  • Oncogenesis

Background:

  • Malignant cells display significant metabolic changes.
  • The let-7 microRNA and Lin28 RNA-binding protein pathway regulates embryonic development.
  • Lin28 is an oncogene that promotes tumorigenesis by suppressing let-7.

Purpose of the Study:

  • To review the current understanding of how Lin28 affects cellular metabolism.
  • To explore the regenerative and oncogenic effects mediated by metabolic mechanisms of Lin28.

Main Methods:

  • Literature review of studies on Lin28, let-7, and cellular metabolism.
  • Analysis of the role of Lin28 in regulating glucose metabolism.
  • Examination of the metabolic reprogramming during tissue repair and injury.

Main Results:

  • The Lin28/let-7 pathway is implicated in regulating glucose metabolism in adult mice.
  • Lin28 reprograms cellular metabolism during tissue injury and repair.
  • Lin28's oncogenic program is increasingly understood through its metabolic effects.

Conclusions:

  • The Lin28/let-7 pathway plays a critical role in metabolic regulation.
  • Lin28 utilizes metabolic mechanisms to promote both regeneration and oncogenesis.
  • Further research into these metabolic underpinnings is crucial for understanding cancer and development.
Keywords:
Lin28, let-7cancermetabolismregeneration

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