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Related Experiment Videos

Nimodipine in acute ischemic stroke: a double-blind controlled study.

A Paci1, P Ottaviano, A Trenta

  • 1Neurological Department, S. Maria Hospital, Terni, Italy.

Acta Neurologica Scandinavica
|October 1, 1989
PubMed
Summary

Nimodipine, a calcium channel blocker, showed potential benefits in treating acute ischemic stroke patients by improving neurological deficits. This study suggests nimodipine may be a valuable therapeutic option for acute stroke recovery.

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Acute ischemic stroke is a leading cause of death and disability.
  • Nimodipine, a dihydropyridine derivative, has demonstrated neuroprotective effects in preclinical models of cerebral ischemia.

Purpose of the Study:

  • To evaluate the efficacy and safety of nimodipine in patients with acute ischemic stroke.
  • To compare the effects of nimodipine versus placebo on neurological deficit recovery.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving 41 patients with acute ischemic stroke.
  • Patients received either nimodipine (40 mg t.i.d.) or placebo for 28 days, initiated within 12 hours of symptom onset.
  • Neurological deficits were assessed using a modified Mathew Scale.

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Main Results:

  • Nimodipine treatment resulted in a higher rate of improvement in neurological deficit scores compared to placebo.
  • Nimodipine was generally well-tolerated, with no severe cardiovascular adverse events reported.
  • One patient experienced a skin rash, but its relation to nimodipine was unclear.

Conclusions:

  • Nimodipine may be beneficial in the treatment of acute ischemic stroke.
  • The study suggests nimodipine improves neurological outcomes in acute stroke patients.
  • Nimodipine demonstrates a favorable safety profile in this patient population.