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Updated: Aug 13, 2026
Dissection of Human Vitreous Body Elements for Proteomic Analysis
Published on: January 23, 2011
Serum and Vitreous Pentraxin 3 Concentrations in Patients with Diabetic Retinopathy
11 Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University , Tianjin, People's Republic of China .
Objective:
Pentraxin 3 (PTX3), an acute-phase glycoprotein, is correlated with inflammation. Inflammation is mechanistically involved in the development of diabetic retinopathy (DR). This study was performed to investigate the association of serum and vitreous PTX3 concentrations with the occurrence of DR.
Methods:
This study enrolled 52 type 2 diabetes mellitus (T2DM) patients (20 without DR and 32 patients with proliferative diabetic retinopathy [PDR]). Serum and vitreous PTX3 concentrations were examined by using an enzyme-linked immunosorbent assay.
Results:
PDR patients showed significantly increased concentrations of serum and vitreous PTX3 concentrations compared with the control group and T2DM patients without DR. Higher serum and vitreous PTX3 concentrations were detected in T2DM patients without DR than those in the controls.
Conclusion:
Serum and vitreous PTX3 concentrations are associated with the occurrence of DR.
