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Aberrant network connectivity during error processing in patients with schizophrenia.

Rolf Voegler1, Michael P I Becker1, Alexander Nitsch1

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Summary
This summary is machine-generated.

Schizophrenia patients show impaired brain network connectivity, particularly involving the right anterior insula (AI), affecting error detection and cognitive control. This task-based fMRI study highlights aberrant functional connectivity crucial for adaptive functioning.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Schizophrenia is linked to large-scale brain network interaction deficits.
  • Abnormal connectivity of the right anterior insula (AI), a salience network hub, is implicated in cognitive control impairments.
  • Previous research primarily used resting-state methods, necessitating task-based investigations.

Purpose of the Study:

  • To investigate right anterior insula (AI) interactions during a cognitive task in schizophrenia.
  • To examine functional connectivity differences between schizophrenia patients and healthy controls.

Main Methods:

  • Utilized a task-based functional MRI (fMRI) approach.
  • Employed an adaptive Eriksen Flanker task ensuring comparable error rates between groups.
  • Included 27 schizophrenia patients and 27 healthy controls.

Main Results:

  • Replicated reduced midcingulate cortex (MCC) activation in schizophrenia patients during error commission, controlling for performance.
  • Revealed aberrant functional connectivity (FC) between the right AI and inferior frontal gyrus/temporoparietal junction.
  • Observed reduced FC between the MCC and dorsolateral prefrontal cortex.

Conclusions:

  • Schizophrenia is associated with impaired networks for error detection, attention, and cognitive control coordination.
  • Medication effects may have influenced the observed results in this medicated patient sample.