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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Fungal Group Zygomycota01:29

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Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
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Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
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Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Cutaneous Manifestation of Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: A Clue to A Gastrointestinal Malignancy.

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Association of a Dominant T-Cell Clone in Peripheral Blood With Time to Systemic Treatment in Patients With Stage IB Mycosis Fungoides.

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Mycosis Fungoides.

Laura B Pincus1

  • 1Departments of Dermatology and Pathology, Section of Dermatopathology, University of California, San Francisco, 1701 Divisadero Street, Suite 280, San Francisco, CA 94115, USA.

Surgical Pathology Clinics
|February 4, 2016
PubMed
Summary

This review covers mycosis fungoides (MF), a common skin T-cell lymphoma. It details MF epidemiology, clinical and microscopic features, diagnosis, and prognosis.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma.
  • Accurate diagnosis and understanding prognosis are crucial for patient management.

Purpose of the Study:

  • To provide a comprehensive review of mycosis fungoides.
  • To cover epidemiology, clinical and microscopic features, diagnostic methods, differential diagnoses, and prognosis.

Main Methods:

  • Literature review and synthesis of existing research on mycosis fungoides.
  • Discussion of diagnostic criteria, including histopathology and ancillary testing.
  • Analysis of prognostic factors and disease progression risks.

Main Results:

Keywords:
Cutaneous T-cell lymphomaCutaneous oncologyMycosis fungoidesSkin lymphoma

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  • Epidemiologic features of MF are presented.
  • Clinical and microscopic findings are described.
  • Diagnostic approaches, differential diagnoses, and prognostic indicators are detailed.

Conclusions:

  • Mycosis fungoides diagnosis relies on integrating clinical, histopathologic, and ancillary test findings.
  • Distinguishing MF from mimics is essential for appropriate treatment.
  • Understanding prognosis aids in managing disease progression risk.