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Pathology of Vulvar Neoplasms
1Department of Pathology, Weill Medical College of Cornell University, 525 East 68th Street, ST-1041, New York, NY 10065, USA.
Surgical Pathology Clinics
|February 4, 2016
Summary
Vulvar cancer is rare, primarily affecting women over 60. Squamous cell carcinoma, the most common type, is linked to chronic inflammation or human papillomaviruses.
Area of Science:
- Gynecologic Oncology
- Dermatopathology
- Oncology
Background:
- Vulvar cancer is an uncommon malignancy, representing 4% of female genital cancers.
- It predominantly affects women over 60, with squamous cell carcinoma being the most frequent histologic type.
- Two main subtypes of squamous cell carcinoma exist: keratinizing and basaloid/warty.
Purpose of the Study:
- To review the etiology, pathogenesis, and histologic features of vulvar carcinoma.
- To differentiate between major subtypes of squamous cell carcinoma.
- To discuss vulvar glandular neoplasms.
Main Methods:
- Literature review of vulvar carcinoma.
- Classification of squamous cell carcinoma subtypes based on etiology and histology.
- Description of glandular neoplasms.
Main Results:
- Squamous cell carcinomas are categorized into keratinizing types (linked to chronic inflammation) and basaloid/warty types (linked to high-risk human papillomaviruses).
- Glandular neoplasms originate from vulvar apocrine sweat glands or Bartholin glands.
- The etiology of vulvar glandular neoplasms is currently unknown.
Conclusions:
- Understanding the distinct origins and associations of vulvar squamous cell carcinoma subtypes is crucial for diagnosis and management.
- Further research is needed to elucidate the causes of vulvar glandular neoplasms.
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