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Updated: Mar 26, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Assessing Biological Aggression in Adrenocortical Neoplasia
Isobel C Mouat1, Thomas J Giordano2
1Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA.
Abstract:
Pathologists are highly skilled at the evaluation of adrenal neoplasms. Occasional adrenocortical tumors can be diagnostically challenging and supplementary tools can assist in these cases. Histologic and molecular studies support a model that includes 2 broad classes of adrenocortical carcinoma with distinct somatic genetic alterations and clinical outcomes. Pathologists should endeavor to grade adrenocortical carcinomas to assign each case into one of these 2 classes. Mitotic grading by mitotic counting and Ki-67 immunohistochemistry represent the most practicable and informative methods currently available.
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