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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
6.7K
Reticular Dermis01:15

Reticular Dermis

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
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Spinal Nerves: Plexus I01:22

Spinal Nerves: Plexus I

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Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Spinal Nerves: Plexus II01:21

Spinal Nerves: Plexus II

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The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
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Related Experiment Video

Updated: Mar 26, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
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Dermal and Subcutaneous Plexiform Soft Tissue Neoplasms.

Hillary Elwood1, Janis Taube2

  • 1Department of Pathology, The Johns Hopkins Hospital, Path 401, 600 North Wolfe Street, Baltimore, MD 21287, USA.

Surgical Pathology Clinics
|February 4, 2016
PubMed
Summary
This summary is machine-generated.

This review details soft tissue tumors with plexiform histomorphology. It covers common types like plexiform schwannoma and neurofibroma, aiding diagnosis and understanding of these rare neoplasms.

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Area of Science:

  • Pathology
  • Oncology
  • Dermatology

Background:

  • Soft tissue tumors encompass a diverse group of neoplasms.
  • Plexiform histomorphology is a distinctive growth pattern observed in certain soft tissue tumors.
  • Accurate diagnosis is crucial for appropriate management and prognosis.

Purpose of the Study:

  • To provide a comprehensive overview of soft tissue tumors exhibiting plexiform histomorphology.
  • To discuss common and rare entities with this specific microscopic appearance.
  • To detail key diagnostic features, including clinical presentation, microscopic findings, and ancillary studies.

Main Methods:

  • Literature review of soft tissue tumors with plexiform histomorphology.
  • Detailed discussion of commonly encountered entities.
  • Inclusion of information on clinical presentation, microscopic features, ancillary studies, differential diagnosis, and prognosis.

Main Results:

  • Identification and detailed description of key soft tissue tumors with plexiform growth.
  • Highlighting of entities such as plexiform fibrohistiocytic tumor, cellular neurothekeoma, dermal nerve sheath myxoma, plexiform schwannoma, and plexiform neurofibroma.
  • Provision of differential diagnostic considerations and prognostic information for each tumor type.

Conclusions:

  • Plexiform histomorphology is a unifying feature for a spectrum of soft tissue tumors.
  • Understanding these specific entities is essential for accurate pathological diagnosis.
  • This overview serves as a resource for clinicians and pathologists managing these rare tumors.