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Related Experiment Video

Updated: Mar 26, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Selected Lesions Featuring Giant Cells.

Karokh H Salih¹, Aatur D Singhi², Elizabeth A Montgomery²

¹Department of Pathology, College of Medicine, University of Sulaimani, As-Sulaimaniyah, Iraq.

Surgical Pathology Clinics

|February 4, 2016

Summary

This article reviews soft tissue neoplasms characterized by giant cells, including tenosynovial giant cell tumor and reticulohistiocytoma. It details various giant cell-rich tumors for better understanding and diagnosis.

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Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Published on: January 25, 2017

Area of Science:

Pathology
Oncology
Dermatology

Background:

Giant cells are present in many soft tissue neoplasms.
This article focuses on specific entities where giant cells are a prominent feature.

Purpose of the Study:

To review and describe soft tissue neoplasms with a striking giant cell component.
To differentiate between various giant cell-rich tumors.

Main Methods:

Literature review and synthesis of existing knowledge on giant cell-rich soft tissue tumors.
Classification and description of key entities based on pathological features.

Main Results:

Identified and discussed tenosynovial giant cell tumor (localized and diffuse), reticulohistiocytoma, juvenile xanthogranuloma.
Described giant cell fibroblastoma, giant cell angiofibroma, and phosphaturic mesenchymal tumor as other significant giant cell-rich neoplasms.

Conclusions:

Giant cells are a significant feature in several distinct soft tissue neoplasms.
Accurate identification and classification of these tumors are crucial for appropriate patient management.