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Updated: Mar 26, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
Genetics and Epigenetics of Chronic Allograft Dysfunction in Kidney Transplants
Sepideh Zununi Vahed, Nasser Samadi, Elmira Mostafidi
1Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ardalan34@yahoo.com.
Abstract:
Chronic allograft dysfunction is the most common cause of allograft lost. Chronic allograft dysfunction happens as a result of complex interactions at the molecular and cellular levels. Genetic and environmental factors both influence the evolution and progression of the chronic allograft dysfunction. Epigenetic modification could be considered as a therapeutically modifiable element to pause the fibrosis process through novel strategies. In this review, the PubMed database was searched for English-language articles on these new areas.
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